Synthesis and Application of Quaternary Ammonium Salt Phase Transfer Catalyst TPBAB
Heterogeneous reaction is an important subject in organic synthesis.The phase transfer catalyst of tripropyl butyl ammonium bromide(TPBAB)was prepared by heating-refluxing-rotating-evaporating-cooling-crystallizing-drying-suction filtration-filtration.During the experiment,the reaction solvent,reaction temperature,reaction time,material ratio,crystallization solvent and other conditions were studied,and the optimum technological conditions for synthesizing TPBAB were determined by response surface method:material ratio n(tri-n-propylamine)∶n(n-butyl bromide)=1∶1.1,reaction temperature:80℃,reaction time:12 h,and reaction solvent:acetonitrile.It was qualitatively analyzed by IR,HNMR and HPLC.From the results,the obtained product does contain the target substance.Through the application in the synthesis of benzyl derivatives of norfloxacin,it is proved that the obtained products have certain activity.
quaternary ammonium salt phase transfer catalysttripropyl butyl ammonium bromidequalitative analysisproduct characterizati
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