The traditional synthesis of aminomalonic acid is complex and time-consuming.Therefore,research focuses on the efficient synthesis of aminomalonic acid,using high-purity reagents and key instruments such as heated stirrers and infrared spectrometers.By optimizing the preparation of Ni/SiO2 catalyst and hydrogenation reaction conditions,the synthesis of high-purity AMA was achieved in a customized reaction device,and the product purity was verified by HPLC.Research results show that when the nickel content in the Ni/SiO2 catalyst is 30%,the reaction temperature is 100℃,and the pressure is 1.8 MPa,the efficiency of hydrogenating 2-NMA to synthesize AMA is optimal,achieving a conversion rate and selection higher than 99%.The optimal dosage of catalyst is 5%of the mass of 2-NMA.The product structure was verified by spectral analysis,confirming the successful synthesis of AMA.
关键词
氨基丙二酸/2-氨基-4-乙酰氨基苯甲醚/加氢工艺
Key words
AMA/2-amino-4-acetamidoanisole/hydrogenation process
维普
万方数据