Research on the Preparation and Purification Methods of 2,2,6,6-tetramethyl-3,5-heptanedione
2,2,6,6-tetramethyl-3,5-heptanedione(TMHD)was prepared using methyl valerate and pinalone as the main raw materials under the action of a condensing agent.Experimental screening and comparison were conducted to determine the ratio of condensing agent,methyl valproate,and pinalone,as well as the purification method for post-treatment.The suitable process for industrial scaling up was determined to be sodium tert butoxide as the condensing agent,with a ratio between 1.2 and 1.4.TMHD with a purity of over 99%can be obtained by dissolution crystallization,which is higher than the purity of commercially available products.And this method has a high recovery rate and is not limited by the production capacity of distillation equipment.
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