As a wide range of drug carriers,nanoparticles can effectively protect the medicinal properties of carrying drugs through the biofilms and increase the slow release time.Compared with traditional drugs,vesicles re-present the biofilm phospholipid bilayer structure,and drugs relying on nanoparticles into the cell membrane have lower damage and better targeting to the cell membrane.We study the process of nanoparticle cross-membrane transport using self-consistent mean-field theory.In the initial state,the nanoparticles have some distance from the vesicle,and as the distance between the nanoparticles and the vesicles decreases,it is shown that the nanoparticles will form specific channels by squeezing the vesicle,thus prompting the particles into the vesicle.This paper discus-ses the changes of free energy,entropy and enthalpy in the process of entering nanoparticles of different shapes.Through the analysis of free energy,entropy and enthalpy change curves,the most appropriate shape of nanoparticles is selected as rod nanoparticles,and finds the best shape of nanoparticles through the membrane.Our results provide good guidance for the experimental design of nanodrug carriers.
关键词
纳米粒子/细胞膜/跨膜运输/自洽场方法
Key words
nanoparticle/cell membrane/transmembrane transport/self-consistent field theory
维普
万方数据