Efficacy of Xinshuai Baoyuan decoction in the treatment of heart failure with preserved ejection fraction after PCI and its effect on serum Gal-3 and sST2
Objective:To investigate the efficacy of Xinshuai Baoyuan decoction in the treatment of heart failure with preserved ejection fraction(HFpEF)after percutaneous coronary intervention(PCI)and its effect on serum ga-lectin 3(Gal-3)and soluble oncogenic inhibitor 2(sST2).Methods:A total of 86 patients with HFpEF after PCI were randomly divided into two groups:the control group(n=43)received conventional western medicine treat-ment,and the observation group(n=43)was treated with Xinshuai Baoyuan decoction on the basis of the control group,and the course of treatment was 12 weeks.The clinical efficacy of the two groups was recorded,and the rele-vant cardiac function indexes,echocardiographic indicators,serum Gal-3 and sST2 levels were compared between the two groups before and after treatment.Results:The total clinical effective rate of observation group was higher than control group(P＜0.05).Compared with before treatment,Lee's heart failure score,NYHA grade,serum N-termi-nal pro-brain natriuretic peptide(NT-proBNP),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)and left ventricular mass index(LVMI)were significantly reduced in the two groups af-ter treatment(P＜0.05),and the reduction degree in the observation group was higher than that in the control group(P＜0.05).The peak blood flow(E/A)of advanced mitral valve increased(P＜0.05),and the increase degree in the observation group was higher than that in the control group(P＜0.05).Compared with before treatment,the serum levels of Gal-3 and sST2 in the two groups were significantly decreased after treatment(P＜0.05),and the reduction degree in the observation group was higher than that in the control group(P＜0.05).Conclusion:On the basis of Western medicine treatment,the addition of Xinshuai Baoyuan decoction can effectively improve the clinical efficacy of HFpEF after PCI,inhibit ventricular remodeling,improve cardiac function,and down-regulate the expression levels of serum Gal-3 and sST2,which is conducive to reducing the incidence of cardiovascular adverse events.
Heart failure with preserved ejection fractionXinshuai Baoyuan decoctionPercutaneous coronary interventionGgalectin 3Soluble carcinogenic inhibitor 2Cardiac function
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维普
