Clinical study on the treatment of diabetic nephropathy with Jianpi Xiezhuo Jiedu prescription
Objective:To observe the effects of Jianpi Xiezhuo Jiedu prescription on inflammatory factors,oxida-tion factors,blood glucose,renal function,intestinal flora and other indexes in diabetic nephropathy(DN)patients.Methods:A total of 100 diabetic nephropathy patients were included,and their scores were divided into two groups by random number method.The control group was treated with conventional therapy,and the observation group was treated with Jianpi Xiuzhu Jiedu prescription.Inflammatory factors(CRP,TNF-α,IL-6),blood glucose(PBG,FBG,HbA1c),renal function(UALB,BUN,eGFR),oxidation factors(SOD,MDA,TAOC),immune factors(CD3+,CD4+,CD4+/CD8+)and intestinal flora(bifidum)were compared between the two groups before and after treat-ment(Bacillus,Lactobacillus,Bacteroides,Enterococcus,Escherichia coli).Results:After treatment,the levels of CRP,TNF-a,IL-6,MDA,CD8+,PBG,FBG,HbA1c and enterococcus in observation group were significantly de-creased,and the levels found in the observation group were considerably lower than the ones in the control group.SOD,TAOC,CD3+,CD4+,CD4+/CD8+ratio,eGFR and the number of bifidobacterium,Moreover,SOD,TAOC,CD3+,CD4+,CD4+/CD8+ratio,eGFR and beneficial bacteria in observation group were significantly higher than those in control group(P＜0.05).Conclusion:Jianpi Xiezhuo Jiedu prescription in the treatment of diabetic nephrop-athy can not only significantly reduce the body inflammatory response of patients,enhance the immune level,but also help to improve the blood sugar level,oxidation factor level and renal function index of patients,and at the same time,it is conducive to the increase of beneficial bacteria in the intestinal tract of the body,with significant curative effect.
Diabetic nephropathyJianpi Xiezhuo Jiedu prescriptionIntestinal floraOxidation factorImmune factorRenal function
万方数据
维普
