The effect of Jianpi Zhidong decoction combined with thumb-tack needle on the treatment of children with tourette syndrome
Objective:To explore the effect of Jianpi Zhidong decoction combined with thumb-tack needle in the treatment of children with tourette syndrome and its impact on neurotransmitters.Methods:96 children with tourette syndrome were included as the study subjects,and then divided into the observation group and control group in a ran-dom manner,each of 48 cases.The observation group was treated with Jianpi Zhidong decoction in combination with thumb-tack needle,while the control group received oral haloperidol tablets.The changes in YGTSS scores,serum neurotransmitter levels[dopamine(DA),norepinephrine(NE),glutamate(GLU),gamma aminobutyric acid(GABA)]before and after treatment was compared,as well as clinical efficacy.Results:After treatment,both groups of children showed a significant decrease in their YGTSS scores for motor and vocal tics,with the observation group showing a more pronounced decrease(P＜0.05).After treatment,serum levels of DA,NE,and GLU were significantly reduced in both groups of children,while GABA was increased significantly,but the changes were more significant in the observation group,and the differences were all significant(P＜0.05).The total effective rate of treatment was 95.83％in the observa-tion group,which was higher than the 83.33％observed in the control group(P＜0.05).Conclusion:Jianpi Zhidong decoc-tion in combination with thumb-tack needle can effectively improve the clinical symptoms of children with tourette syn-drome,regulate neurotransmitter imbalances,and thereby enhance clinical efficacy.
万方数据
维普
