Mechanisms and research progress of Hedgehog signaling pathway in the ovary
The Hedgehog signaling pathway is a highly conserved signaling pathway during evolution.It plays an important role in female mammalian gonadal development and functional maintenance.And involved in regulating the differentiation of various cells in the ovary,maintaining the stability of ovarian structure and function,and promo-ting follicular maturation and expulsion.In this paper,we briefly summarize the main mechanisms of Hedgehog sig-naling pathway in mammalian ovarian development,germline stem cell transformation,follicular development and atresia,and ovarian cancer development,with a view to providing some ideas for the treatment of related diseases.
Hedgehog signaling pathwayOvaryFemale germline stem cellFollicular developmentFollicu-lar atresiaOvarian cancer
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