The Hedgehog signaling pathway is a highly conserved signaling pathway during evolution.It plays an important role in female mammalian gonadal development and functional maintenance.And involved in regulating the differentiation of various cells in the ovary,maintaining the stability of ovarian structure and function,and promo-ting follicular maturation and expulsion.In this paper,we briefly summarize the main mechanisms of Hedgehog sig-naling pathway in mammalian ovarian development,germline stem cell transformation,follicular development and atresia,and ovarian cancer development,with a view to providing some ideas for the treatment of related diseases.
关键词
Hedgehog信号通路/卵巢/卵巢生殖干细胞/卵泡发育/卵泡闭锁/卵巢癌
Key words
Hedgehog signaling pathway/Ovary/Female germline stem cell/Follicular development/Follicu-lar atresia/Ovarian cancer
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