首页|Rotenone induces more serious learning and memory impairment than α-synuclein A30P does in Drosophila

Rotenone induces more serious learning and memory impairment than α-synuclein A30P does in Drosophila

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Parkinson's disease (PD) is a heterogenous disease caused by multifactorial etiology. PD is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra and the accumulation of Lewy bodies. In this study, two Drosophila PD models by exposing Drosophila to rotenone (sporadic PD models) are proposed, and the human α-synuclein A30P protein (family PD models) in Drosophila is expressed respectively. Both models recapitulated the main human PD symptoms including the loss of dopaminergic neurons in the brain and severe locomotor deficits. Our study finds that Rotenone induces more serious learning and memory impairment than α-synuclein A30P does.

Parkinson's disease (PD)rotenoneα-synuclein A30Plearning and memory

YU Shu、JIANG Meng、XIA Ying、CHEN Qiu-yu、WEN Tie-qiao

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School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China

Institute of Systems Biology, Shanghai University, Shanghai 200444, P. R. China

Major State Basic Research and Development Program of China国家自然科学基金Innovation Foundation of Shanghai Commission of Education Science and TechnologyBasic Research Foundation of Shanghai Commission of Science and TechnologyBasic Research Foundation of Shanghai Commission of Science and Technology

2006CB5007023107095408ZZ4103JC1403009JC1406600

2011

10.1007/s11741-011-0726-2

上海大学学报(英文版)
上海大学

上海大学学报(英文版)

影响因子：0.196
ISSN：1007-6417
年,卷(期)：2011.15(3)
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