基于薄膜晶体管的冠状病毒检测研究进展

Research progress in coronavirus detection based on thin-film transistors

涂建新 ¹郝魁 ¹孙乐 ²李爱军¹

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作者信息

1. 上海大学材料科学与工程学院,上海 200444;上海大学绍兴研究院,浙江绍兴 312000
2. 上海大学绍兴研究院,浙江绍兴 312000
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摘要

薄膜晶体管(thin-film transistors,TFTs)已广泛应用于生物电子学领域,用来检测代谢物、核酸、蛋白质、细胞活动和电生理信号.在新冠病毒大流行期间,基于TFTs的COVID-19生物传感器展现出良好的性能和高应用潜力.石墨烯场效应晶体管(graphene field-effect transistors,GFETs)、氧化物薄膜晶体管、有机场效应晶体管(organic field-effect transistors,OFETs)和有机电化学晶体管(organic electrochemical transistors,OECTs)等薄膜晶体管在病毒、RNA、抗原、抗体的检测中均取得了良好的结果.总结了基于薄膜晶体管的新冠病毒和相关生物标志物检测的生物传感器,讨论了基于不同沟道材料晶体管的传感策略.最后,对未来薄膜晶体管应用于病毒检测的研究方向提出展望.

Abstract

Thin-film transistors(TFTs)are widely used in bioelectronics for applications in detecting metabolites,nucleic acids,proteins,cellular activities,and electrophysiologi-cal signals.During the COVID-19 pandemic,TFT-based COVID-19 biosensors displayed excellent performances and high levels of potential for use in various applications.TFTs,such as oxide-based TFTs and graphene field-effect,organic field-effect,and organic elec-trochemical transistors,yielded promising results in detecting viruses,ribonucleic acid,and antigens and antibodies.This review summarizes biosensors based on TFTs for use in detecting SARS-CoV-2 and the related biomarkers and analyzes sensing strategies based on transistors with different channel materials.Finally,future directions for researches regarding the applications of TFTs in viral detection are proposed.

关键词

薄膜晶体管/生物传感器/冠状病毒检测/有机电化学晶体管/有机场效应晶体管

Key words

thin-film transistors/biosensors/corona virus detection/organic electro-chemical transistors/organic field-effect transistors

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出版年

2024

上海大学学报(自然科学版)

上海大学

上海大学学报(自然科学版)

CSTPCDCSCD北大核心

影响因子：0.579

ISSN：1007-2861

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