Abnormalities in signal transduction of Purkinje cells in spinocerebellar ataxias:a review
Spinocerebellar ataxias(SCAs)are a group of autosomal dominant neurodegenerative diseases that have been currently identified with numerous subtypes exhibiting genetic heterogeneity and clinical variability.Purkinje neuronal degeneration and cerebellar atrophy are common pathological features among most SCA subtypes.The physiological functions of Purkinje cells are regulated by multiple factors,and their dysfunction in signal transduction may lead to abnormal cerebellar motor control.This review summarizes the abnormalities in voltage-gated ionic channels,intracellular calcium signaling,and glutamate signaling transduction of Purkinje cells in SCAs,aiming to provide a theoretical basis for further understanding the common pathogenesis of SCAs and devel-oping specific treatments.
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