Research advances of prostaglandin E2 receptor 1(EP1)
Prostaglandin E2(PGE2)is an important lipid molecule derived from arachidonic acid,which regulates a variety of physio-logical and pathological activities.Based on the inhibition of inflammatory PGE2 production,non-steroidal anti-inflammatory drugs(NSAIDs)are considered as the most commonly used drugs to treat inflammatory diseases and to relieve fever and pain symptoms.PGE2 mediates its functions via four different G protein-coupled receptors,named EP1-EP4.Though the limited distribution and low PGE2 affinity of EP1,it plays important roles in the maintenance of many physiological functions and homeostasis.Moreover,EPl is widely involved in the inflammatory response,pain perception and multisystem pathological function regulation.In this review,we will briefly summarize the recent advances on the physiological and pathophysiological function of EPl and its targeted drugs development.
prostaglandin E2EP1inflammation
陈书涛、季爽、郭美娜、陈丽红
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大连医科大学基础医学院,大连 116044
大连医科大学医学科学研究院,大连 116044
前列腺素E2 前列腺素E2受体亚型1 炎症
National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaLiaoning Science and Technology Department Program,China
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