非编码RNA参与肝细胞癌糖酵解调控的研究进展
Research progress of non-coding RNA involved in glycolysis regulation of hepatocellular carcinoma
胡晓峰 1张青 1梁美铝 1周青鸟 1赵瑞强 1龚祖康 2林文珍1
作者信息
- 1. 广西医科大学基础医学院生物化学与分子生物学教研室,南宁 530021;广西高校生物分子医学研究重点实验室,南宁 530021
- 2. 南宁市疾病预防控制中心,南宁 530021
- 折叠
摘要
肝癌是一种常见的消化系统肿瘤,肝细胞癌(hepatocellular carcinoma,HCC)作为一种较为常见的肝癌类型,其恶性程度高且在全球癌症相关死亡原因中排在前列.代谢重编程被认为是癌症发生和发展的一个重要标志,糖代谢是细胞产生能量的主要途径之一.糖酵解作为糖代谢的基础性反应在细胞的代谢中发挥着举足轻重的作用,因此糖酵解的调控对于肿瘤的增殖与演变有着重要意义.越来越多的非编码RNA(non-coding RNA,ncRNA)被证实在肿瘤的糖酵解调控中发挥重要作用.本文综述了ncRNA在HCC糖酵解调控中的作用及相关机制,同时对基于糖酵解调控相关机制的靶向治疗HCC的方法提出展望.
Abstract
Liver cancer is a common tumor of digestive system.Hepatocellular carcinoma(HCC)is a common type of liver cancer,which has a high degree of malignancy and ranks among the top causes of cancer-related death in the world.Metabolic reprogram-ming is considered to be an important marker of carcinogenesis.Glucose metabolism is one of the main ways for cells to produce energy.Glycolysis,as the basic reaction of glucose metabolism,plays an important role in cell metabolism.Therefore,the regulation of glycolysis is of great significance to the proliferation and evolution of tumors.More and more non-coding RNAs(ncRNA)have been proved to play an important role in the regulation of tumor glycolysis.This article reviews the role of ncRNA in the regulation of HCC glycolysis and its related mechanisms.At the same time,the prospect of targeted therapy for HCC based on the related mecha-nisms of glycolysis regulation is put forward.
关键词
肝细胞癌/非编码RNA/糖代谢重编程/糖酵解调控Key words
hepatocellular carcinoma/non-coding RNA/glucose metabolism reprogramming/glycolysis regulation引用本文复制引用
基金项目
国家自然科学基金(81660464)
国家自然科学基金(32260164)
广西自然科学基金(2016GXNSFAA026080)
广西自然科学基金(2023GXNSFAA026080)
出版年
2024
NETL
NSTL
万方数据