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MicroRNA在脊髓损伤中的研究进展

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脊髓损伤(spinal cord injury，SCI)是一种严重的中枢神经系统疾病，致残率和死亡率较高，具有复杂的病理生理机制。微小RNA(microRNA，miRNA)作为一种非编码RNA，在SCI中发挥重要作用。miRNA参与SCI后的炎症反应、氧化应激、轴突再生、细胞凋亡等的调控，并与长链非编码RNA(long non-coding RNA，lncRNA)、环状RNA(circular RNA，circRNA)相互作用调节SCI的病理生理过程。本文归纳了SCI后miRNA的表达变化，综述了miRNA在SCI中的靶向机制及miRNA靶向药物的研究现状，为SCI的基础和临床研究提供新靶点和新视野。
Research progress of microRNA in spinal cord injury
Spinal cord injury(SCI)is a serious central nervous system disease with high disability and mortality rates and complex pathophysiologic mechanisms.MicroRNA(miRNA),as a kind of non-coding RNA,plays an important role in SCI.miRNA is involved in the regulation of inflammatory response,oxidative stress,axonal regeneration,and apoptosis after SCI,and interacts with long non-coding RNA(lncRNA)and circular RNA(circRNA)to regulate the pathophysiological process of SCI.This paper summarizes the changes in miRNA expression after SCI,and reviews the targeting mechanism of miRNA in SCI and the current research status of miRNA-targeted drugs to provide new targets and new horizons for basic and clinical research on SCI.

spinal cord injurymicroRNAinflammatory responseoxidative stressaxonal regenerationapoptosisautophagyferroptosis

魏栋敏、方蕊、邓智中、白心悦、朱晶惠、翟天宇、张灿、高建忠、苏丹、杨彦玲、赵琳

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延安大学医学院,延安 716000

德州市第二人民医院医学影像科,德州 254300

榆林市第一人民医院神经外科,榆林 719000

脊髓损伤 microRNA 炎症反应 氧化应激 轴突再生 细胞凋亡 自噬 铁死亡

National Natural Science Foundation of ChinaShaanxi Social Development of Science and Technology ProjectShaanxi University Student Innovation Training Program Project

816410482021SF-082S202210719067

2024

10.13294/j.aps.2024.0026

生理学报
中国科学院上海生命科学研究院,中国生理学会

生理学报

CSTPCD北大核心
影响因子：0.864
ISSN：0371-0874
年,卷(期)：2024.76(3)