MicroRNA在脊髓损伤中的研究进展
Research progress of microRNA in spinal cord injury
魏栋敏 1方蕊 2邓智中 1白心悦 1朱晶惠 1翟天宇 1张灿 1高建忠 3苏丹 1杨彦玲 1赵琳1
作者信息
- 1. 延安大学医学院,延安 716000
- 2. 德州市第二人民医院医学影像科,德州 254300
- 3. 榆林市第一人民医院神经外科,榆林 719000
- 折叠
摘要
脊髓损伤(spinal cord injury,SCI)是一种严重的中枢神经系统疾病,致残率和死亡率较高,具有复杂的病理生理机制.微小RNA(microRNA,miRNA)作为一种非编码RNA,在SCI中发挥重要作用.miRNA参与SCI后的炎症反应、氧化应激、轴突再生、细胞凋亡等的调控,并与长链非编码RNA(long non-coding RNA,lncRNA)、环状RNA(circular RNA,circRNA)相互作用调节SCI的病理生理过程.本文归纳了SCI后miRNA的表达变化,综述了miRNA在SCI中的靶向机制及miRNA靶向药物的研究现状,为SCI的基础和临床研究提供新靶点和新视野.
Abstract
Spinal cord injury(SCI)is a serious central nervous system disease with high disability and mortality rates and complex pathophysiologic mechanisms.MicroRNA(miRNA),as a kind of non-coding RNA,plays an important role in SCI.miRNA is involved in the regulation of inflammatory response,oxidative stress,axonal regeneration,and apoptosis after SCI,and interacts with long non-coding RNA(lncRNA)and circular RNA(circRNA)to regulate the pathophysiological process of SCI.This paper summarizes the changes in miRNA expression after SCI,and reviews the targeting mechanism of miRNA in SCI and the current research status of miRNA-targeted drugs to provide new targets and new horizons for basic and clinical research on SCI.
关键词
脊髓损伤/microRNA/炎症反应/氧化应激/轴突再生/细胞凋亡/自噬/铁死亡Key words
spinal cord injury/microRNA/inflammatory response/oxidative stress/axonal regeneration/apoptosis/autophagy/ferroptosis引用本文复制引用
基金项目
National Natural Science Foundation of China(81641048)
Shaanxi Social Development of Science and Technology Project(2021SF-082)
Shaanxi University Student Innovation Training Program Project(S202210719067)
出版年
2024
NETL
NSTL
万方数据