摘要
Chemerin作为一种多功能脂肪因子,通过内分泌和旁分泌起作用,它可以与已知的三个受体(ChemR23、GPR1和CCRL2)结合参与能量代谢、糖脂代谢和炎症等多种病理生理过程,尤其在代谢性疾病中发挥重要作用.多囊卵巢综合征(polycystic ovary syndrome,PCOS)是最常见的内分泌疾病之一,严重困扰育龄女性的正常生活.PCOS患者血清chemerin含量显著升高,且其卵巢中chemerin高表达.越来越多的研究表明chemerin通过影响肥胖症、胰岛素抵抗、高雄激素血症、氧化应激和炎症反应等参与PCOS的发生和发展过程.本文主要综述了chemerin蛋白的产生、亚型、功能和受体,从代谢、生殖、炎症等角度总结并探讨chemerin蛋白在PCOS中的研究现状,为PCOS的临床诊断和治疗提供理论基础和参考依据.
Abstract
As a multifunctional adipokine,chemerin plays a crucial role in various pathophysiological processes through endocrine and paracrine manner.It can bind to three known receptors(ChemR23,GPR1 and CCRL2)and participate in energy metabolism,glucose and lipid metabolism,and inflammation,especially in metabolic diseases.Polycystic ovary syndrome(PCOS)is one of the most common endocrine diseases,which seriously affects the normal life of women of childbearing age.Patients with PCOS have significantly increased serum levels of chemerin and high expression of chemerin in their ovaries.More and more studies have shown that chemerin is involved in the occurrence and development of PCOS by affecting obesity,insulin resistance,hyperandrogenism,oxidative stress and inflammatory response.This article mainly reviews the production,subtypes,function and receptors of chemerin protein,summarizes and discusses the research status of chemerin protein in PCOS from the perspectives of metabolism,reproduction and inflammation,and provides theoretical basis and reference for the clinical diagnosis and treatment of PCOS.
基金项目
National Natural Science Foundation of China(82111530101)
National Natural Science Foundation of China(81803493)
Outstanding Youth Foundation of Jiangxi Province,China(20212ACB216002)
Young Jinggang Scholars Award Program of Jiangxi Province,China(QNJG2019089)
NETL
NSTL
万方数据