摘要
半胱氨酸双加氧酶1(cysteine dioxygenase type 1,CDO1)属于半胱氨酸双加氧酶(cysteine dioxygenase,CDO)家族,是半胱氨酸分解代谢和牛磺酸合成代谢的关键酶,主要在肝脏、脂肪、胰腺、肾脏、肺、脑和小肠组织中高表达.CDO1参与多种常见代谢性疾病的病理生理学调控过程,例如脂代谢紊乱、胰岛素抵抗、肥胖、肿瘤/癌症和神经退行性疾病.本文梳理和总结近年CDO1调控常见代谢性疾病的分子作用机制研究进展,以期为靶向CDO1蛋白治疗胰岛素抵抗、肥胖、肿瘤/癌症和神经退行性疾病提供新的理论和实践依据.
Abstract
Cysteine dioxygenase type 1(CDO1)belongs to the cysteine dioxygenase(CDO)family.CDO1 is the key enzyme in cysteine catabolism and taurine synthesis.CDO1 is highly expressed in liver,adipose tissue,pancreas,kidney,lung,brain and small intestine.CDO1 is involved in the pathophysiological regulation of various common metabolic diseases,such as lipid metabolism disorders,insulin resistance,obesity,tumors/cancers,and neurodegenerative diseases.This article summarizes the research progress on the molecular mechanisms of CDO1 regulation of common metabolic diseases in recent years,aiming to provide new theoretical and practical basis for CDO1-targeted therapy for insulin resistance,obesity,tumors/cancers,and neurodegenerative diseases.
基金项目
Natural Science Research Project of Anhui Educational Committee(KJ2021A0096)
Open Subject of Kinesiology in the College of Physical Education,Anhui Normal University(TYKFKT2023002)
General Project of Anhui Normal University(762167)
General Project of Anhui Normal University(2021xjxm051)
维普
万方数据