首页|芳香烃受体在环境污染物损伤雄性哺乳动物生育力中的作用及分子机制

芳香烃受体在环境污染物损伤雄性哺乳动物生育力中的作用及分子机制

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近几十年全球男性精子质量持续下滑,而环境污染是其重要诱因.持久性有机污染物(persistent organic pollutants,POPs)由于具有高生物毒性、耐生物降解等特性而受到广泛关注.POPs中的多环芳烃及卤代芳烃类污染物主要通过激活芳香烃受体(aryl hydrocarbon receptor,AhR)损伤细胞生理功能,然而AhR在环境污染物损伤雄性哺乳动物生育力中的作用仍未被完全阐明.本文综述了多环芳烃型环境污染物苯并[a]芘、3-甲基胆蒽、7,12-二甲基苯并[a]蒽,卤代芳烃型环境污染物2,3,7,8-四氯二苯并对二恶英、多氯联苯、多溴二苯醚以及污染物复合体PM2.5、香烟烟雾冷凝液对雄性哺乳动物生殖功能的影响,并重点阐释了AhR在其中发挥的作用.本综述旨在揭示AhR在雄性哺乳动物生育力调控中所扮演的角色,以期为后续研究AhR与男性生殖功能的联系及临床特发性男性不育症发病机制提供线索.
The involvement and underlying mechanism of the aryl hydrocarbon receptor(AhR)in the impairment of male mammalian fertility induced by environmental pollutants
In recent decades,there has been a consistent decline in semen quality across the globe,with environmental pollution emerging as the predominant factor.Persistent organic pollutants(POPs)have garnered considerable attention due to their potent biological toxicity and resistance to natural degradation.Within this class of pollutants,polycyclic aromatic hydrocarbons(PAHs)and halogenated aromatic hydrocarbons(HAHs)have been identified as detrimental agents that can disrupt cellular physiological func-tions by activating aryl hydrocarbon receptor(AhR).However,the precise role of AhR in the adverse effects of environmental pollutants on male mammalian fertility remains incompletely understood.This article provides a comprehensive review of the impact of various environmental pollutants,specifically PAHs such as benzo[a]pyrene,3-methylcholanthrene,and 7,12-dimethylbenzo[a]anthracene,HAHs including 2,3,7,8-tetrachlorodibenzo-p-dioxins,polychlorinated biphenyls,polybrominated diphenyl ethers,and the pollutant complex PM2.5,as well as cigarette smoke condensates,on male mammalian reproductive function.Additionally,this review focuses on the role of the AhR in mediating these effects.The objective of this review is to elucidate the involvement of AhR in the regulation of male mammalian fertility,thereby offering insights for prospective investigations into the interplay between AhR and male repro-ductive function,as well as the etiology of idiopathic male infertility in clinic.

aryl hydrocarbon receptorsenvironmental pollutantsexogenous AhR ligandsmale mammalian fertilitymolecular mechanisms

杨业斌、彭真、彭圣林、梅光泉、程一民

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宜春学院化学与生物工程学院,江西省天然活性成分重点实验室

宜春市人民医院,宜春 336000

宜春学院医学院

芳香烃受体 环境污染物 芳香烃受体外源性配体 雄性哺乳动物生育力 分子机制

National Natural Science Foundation of ChinaNatural Science Foundation of Jiangxi Province,China

8210169020224BAB216029

2024

10.13294/j.aps.2024.0009

生理学报
中国科学院上海生命科学研究院,中国生理学会

生理学报

CSTPCD北大核心
影响因子：0.864
ISSN：0371-0874
年,卷(期)：2024.76(4)