β-烟酰胺单核苷酸(NMN)抗衰老研究进展
Research progress on anti-aging effects of β-nicotinamide mononucleotide(NMN)
韩苗 1华进联1
作者信息
- 1. 西北农林科技大学动物医学院,陕西省干细胞工程技术研究中心,杨凌 712100
- 折叠
摘要
β-烟酰胺单核苷酸(β-nicotinamide mononucleotide,NMN)是烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide,NAD)的前体物质,在提高NAD水平中发挥重要作用.NMN的摄入能够改变肠道微生物的组成与活力,恢复线粒体功能,抑制炎症通路的激活,发挥改善机体代谢、抗氧化应激及减轻炎症的作用,从而在衰老相关疾病(如心脏功能减退、生育能力降低、记忆障碍、糖尿病)防控中发挥显著的恢复效果,显示出有效且安全的抗衰老作用.中国对NMN的使用已经逐步放开,探究NMN发挥抗衰老作用的机制,提高NMN的生物合成是其广泛应用的重要方向.同时,NMN协同干细胞有望治疗与衰老相关的退行性疾病,促进人类和动物的整体健康.
Abstract
β-Nicotinamide mononucleotide(NMN),as the precursor of nicotinamide adenine dinucleotide(NAD),plays an important role in enhancing NAD levels.Intake of NMN can alter the composition and vitality of gut microbiota,restore mitochondrial func-tion,inhibit inflammatory pathways,improve metabolism,counteract oxidative stress,and alleviate inflammation.NMN significantly improves recovery from aging-related diseases,such as diminished heart function,reduced fertility,memory decline,and diabetes.NMN demonstrates both efficacy and safety in anti-aging.The use of NMN in China has gradually gained acceptance,highlighting the importance of exploring the mechanism of NMN in anti-aging effects and improving the biosynthesis of NMN.In addition,NMN in combination with stem cells hold promise in the treatment of aging-related degenerative diseases and promote overall human and animal health.
关键词
β-烟酰胺单核苷酸(NMN)/衰老/干细胞Key words
β-nicotinamide mononucleotide(NMN)/aging/stem cell引用本文复制引用
出版年
2024
NETL
NSTL
万方数据