光动力学抗菌敷料的研究进展
Research progress of photodynamic antimicrobial dressings
施佳茵 1高晶 1张大志 2阎澜 2王璐1
作者信息
- 1. 东华大学纺织学院,上海 201620
- 2. 海军军医大学药学系,上海 200433
- 折叠
摘要
抗生素的滥用使得耐药微生物不断涌现,探索新的不易产生耐药性的抗微生物治疗方法迫在眉睫.光动力抗菌疗法是通过光敏剂在光激发后产生活性氧来杀灭细菌、真菌、病毒等微生物,抑制生物膜的形成,因此光动力抗菌疗法具有广谱抑菌性和极低的耐药性.临床上常将光敏剂直接涂覆在伤口上用于光动力抗菌,但会产生皮肤刺激过敏的不良反应.为了避免出现副反应,将光敏剂引入水凝胶、纳米纤维等载体材料中可以获得更好的抗菌效果.总结光动力抗菌疗法的作用机制、优势及光动力学抗菌敷料的最新进展,包括单一疗法和协同疗法,为新型敷料的设计与开发提供参考.
Abstract
The abuse of antibiotics has led to the continuous emergence of drug-resistant microorganisms,so it is urgent to explore new antimicrobial treatments with extremely low drug resistance.Photodynamic antibacterial therapy uses photosensitizers to produce reactive oxygen species after light stimulation to kill bacteria,fungi,viruses,and other microorganisms,inhibiting the formation of biofilms.Therefore,photodynamic antibacterial therapy has broad-spectrum antibacterial activity and extremely low drug resistance.In clinical practice,photosensitizers are often applied directly to wounds,which may cause skin irritation and allergic reactions.In order to avoid side effects,photosensitizers are introduced into hydrogels,nanofibers and other carrier materials to obtain better antimicrobial effects.The mechanism and advantages of photodynamic antibacterial therapy and the latest development of photodynamic antimicrobial dressings are summarized,including monotherapy and cotherapy,providing reference for the design and development of new dressings.
关键词
光动力抗菌疗法/活性氧/功能敷料/抗细菌活性/耐药性Key words
photodynamic antimicrobial therapy/reactive oxygen species/functional dressing/antibacterial activity/drug resistance引用本文复制引用
出版年
2024
NETL
NSTL
万方数据