Construction of chitosan-based aerogel drug controlled release system and its application
Drug controlled release system can achieve targeted drug release in a specific environment,stabilize drug concentration,and reduce the toxicity caused by drug burst release.Chitosan-based aerogel is a new class of nanomaterials with three-dimensional porous network structure with solid as the skeleton and gas as the dispersion medium.It shows the characteristics of high specific surface area,high porosity,low density and excellent biocompatibility,and has great application prospect in the field of drug controlled release.Based on the current research status at home and abroad,the construction method and drug loading method of chitosan-based aerogel drug controlled release system are systematically reviewed,the performance and influencing factors of chitosan-based aerogel drug controlled release system are analyzed,and the drug controlled release mechanism of chitosan-based aerogel drug loading system is expounded.The application of chitosan-based aerogel drug controlled release system in the treatment of chronic wounds and cancer is discussed.Finally,the future development direction of chitosan-based aerogel drug loading system with high drug loading,controlled drug release rate and high bioavailability is prospected.
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