Preparation of polycaprolactone/chitosan drug-loaded dressing and its coagulation properties
Wound healing is a complex,dynamic and slow process.In order to accelerate this process,polycaprolactone/chitosan bowl-shaped particles loaded with thrombin are prepared by electrostatic spraying.The microstructure,chemical structure,coagulation properties,blood compatibility and cytotoxicity of the bowl-shaped particles are investigated.The results show that the thrombin@polycaprolactone/chitosan bowl-shaped particles have good blood compatibility and biocompatibility.The haemolysis rate is less than 2％and the cell survival rate is more than 95％.Thrombin can significantly enhance the coagulation properties of polycaprolactone/chitosan beads.The activated partial thromboplastin time and thrombin time of thrombin@polycaprolactone/chitosan bowl-shaped particles are only 21.4 s and 13 s,respectively;the coagulation index of thrombin@polycaprolactone/chitosan bowl-shaped microparticle-coated gauze is much lower than that of ordinary gauze at the same time.
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