Four case reports of a newly defined HEp-2 ANA karyotype AC-29 by indirect immunofluorescence assay
To explore the clinical characteristics of DNA topoisomerase type Ⅰ(AC-29)in human laryngeal carcinoma cell line 2(HEp-2)cells,four cases of AC-29 from Children's Hospital of Nanjing Medical University were retrospectively reported.From January 2020 to December 2021,a total of 14 213 serum samples with auto-antibodies had been tested in this Hospital.Among them,four had the anti-nuclear antibody(ANA)karyotype shaped AC-29 tested by indirect immunofluorescence assay.AC-29 is a newly defined karyotype in recent years.Correct identification of AC-29 has potential significance for early diagnosis of disease.
anti-nuclear antibodyhuman laryngeal carcinoma cell line 2 celldeoxyribonucleic acid topoisomerase type Ⅰ