Research progress on the role of exosome in the ionizing radiation-induced bystander effects in the immune system
Radiation-induced bystander effect(RIBE)is one of the mechanisms of ionizing radiation-induced biological effects,which may be mediated by a variety of pathways.Exosomes are 30～ 150 nm diameter bilayer lipid membrane-rounding vesicles actively released by living cells and were widely distributed in body fluids.They carry signal molecules including nucleic acids and proteins to play important roles in inter-cellular communications.Recently,it has been found that exosomes can participate in the formation of RIBE and mediate the occurrence of immune responses due to ionizing radiation.The immune system is one of the main targets for ionizing radiation,and the damage of the immune system is also the main cause of the most common diseases and life quality decline of patients suffering from nuclear accidents.Therefore,it has persisted a hotspot in the field of radiation biology to comprehensively reveal the mechanism of RIBE in the ionizing radiation-induced immune effect.This review discusses the role of RIBE in the ionizing radiation-induced immune effect from the perspective of exosome and summarizes the biological mechanisms of exosome in this process in order to form a scientific basis for further study of the mechanism of radiation biological effects and for the exploration of radiation injury prevention and treatment strategies.
exosomeradiation-induced bystander effectionizing radiationimmune system
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维普
