Neutrophils are one of the most important effector cells in innate immunity and the defense at the frontline against in-vading pathogens.With the continuous advances,people have realized that neutrophils not only participate in the inflammatory response and tissue damage repair,tumor-associated neutrophils also act as anti- or pro-tumorigenic factors depending on spe-cific tumor microenvironment(TME)status.Neutrophils with different functions may have different phenotypes and also some plasticity.This review begins with the biological properties of neutrophils,and then summarizes the diverse phenotypes of neu-trophils with different functions in the TME,the possible mechanisms of immunosuppressive neutrophils regulating tumor im-munity,and the clinical application of neutrophils in cancer research.
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