Research progress on the role of neutrophils in the tumor microenvironment
Neutrophils are one of the most important effector cells in innate immunity and the defense at the frontline against in-vading pathogens.With the continuous advances,people have realized that neutrophils not only participate in the inflammatory response and tissue damage repair,tumor-associated neutrophils also act as anti- or pro-tumorigenic factors depending on spe-cific tumor microenvironment(TME)status.Neutrophils with different functions may have different phenotypes and also some plasticity.This review begins with the biological properties of neutrophils,and then summarizes the diverse phenotypes of neu-trophils with different functions in the TME,the possible mechanisms of immunosuppressive neutrophils regulating tumor im-munity,and the clinical application of neutrophils in cancer research.
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