在全球新冠疫情愈发严重的当下,记忆细胞在抗病毒感染中的优势使其受到了广泛的关注.最新的研究发现,CD4+记忆T细胞(memory T cell,TM)的分化与效应应答需要特定抗原提呈细胞与微环境中细胞因子的辅助.它们严密地调控着胞内的转录因子及能量代谢.该文总结并讨论了调控CD4+ TM生成、维持及再次应答的关键机制.在不同疾病背景下精准调控CD4+ TM的数量与功能将会是未来的一个巨大挑战.
The mechanism of CD4+T cell memory formation and maintenance
During the global pandemic of COVID-19,memory T cells have drawn increasing research attention because of their superior antiviral capacity.The latest research demonstrates that certain APC and cytokines in the microenvironment are required for the differentiation and effector responses of memory CD4+ T cells via tightly modulated intracellular transcription factors and energy metabolism.This review summarizes and discusses the key mechanisms underlying the development,long-term maintenance,and secondary immune responses of memory CD4+ T cells.Precise regulation of their number and functions in different types of diseases will be a big challenge in the future.
CD4+ memory T cellantigen-presenting cellcytokinetranscription factorenergy metabolism
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