首页|TCR CDR3组库及HLA等位基因与新型冠状病毒肺炎关系的研究概况和进展

TCR CDR3组库及HLA等位基因与新型冠状病毒肺炎关系的研究概况和进展

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新型冠状病毒肺炎(corona virus disease 2019,COVID-19)是由严重急性呼吸系统综合征冠状病毒2型(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)感染所致.机体抗病毒的适应性免疫应答主要依赖T细胞选择性地清除病毒感染宿主细胞,而T细胞受体(Tcell receptor,TCR)的结构决定其对病毒抗原决定簇的特异性识别,感染者TCR互补决定区3(complementarity determining region 3,CDR3)组库的特征在COVID-19的发生与发展中有重要的提示意义.此外,人类白细胞抗原(human leukocyte antigen,HLA)是不同个体对抗原引起免疫应答差异的主要原因,在人体的免疫应答中发挥着重要作用.文章重点概述TCR CDR3组库的特征和HLA等位基因的组成与COVID-19之间关系的研究概况和进展.
Research progress and overview on the relationships between TCR CDR3 repertoire characteristics and the composition of HLA alleles with COVID-19
Corona virus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has become a global health emergency.Adaptive immune response plays a critical role in clearing virus-infected host cells,mainly relying on T cells.The structure of the T cell receptor(TCR)determines the specificity of viral antigen cluster recogni-tion,and the characteristics of the TCR complementarity determining region 3(CDR3)repertoire of infected individuals have indications for the occurrence and development of COVID-19 disease.Additionally,human leukocyte antigen(HLA)gene is the main factor responsible for individual varieties in immune responses to antigens and plays an important role in human immune responses.This review focuses on the research progress and overview of the relationships of TCR CDR3 repertoire characteristics and of the composition of host HLA alleles with COVID-19.

corona virus disease 2019T cell receptor complementarity determining region 3 repertoiresevere acute respiratory syndrome coronavirus 2human leukocyte antigen

周得维、李俊、李洋洋、姚新生

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遵义医科大学 免疫学教研室,遵义 563000

遵义医科大学第三附属医院/遵义市第一人民医院 检验科,遵义 563000

新型冠状病毒肺炎 T细胞受体互补决定区3组库 严重急性呼吸系统综合征冠状病毒2型 人类白细胞抗原

国家自然科学基金地区科学基金国家自然科学基金地区科学基金贵州省百层次人才基金

8216027981860300[2018]5637

2024

现代免疫学
上海市免疫学研究所,上海市免疫学会

现代免疫学

CSTPCD
影响因子：0.4
ISSN：1001-2478
年,卷(期)：2024.44(2)
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