NOX2参与适应性免疫反应及其与慢性肉芽肿病伴随性自身免疫病的联系
Effects of NOX2 in adaptive immune response and its correlation with autoimmune diseases associated with chronic granulomatous disease
苏晓亚 1洪莉 2陈同辛1
作者信息
- 1. 上海交通大学医学院附属上海儿童医学中心 风湿免疫科,上海 200127;上海交通大学医学院附属上海儿童医学中心 儿科转化医学研究所,上海 200127
- 2. 上海交通大学医学院附属上海儿童医学中心 儿科转化医学研究所,上海 200127;上海交通大学医学院附属上海儿童医学中心 临床营养科,上海 200127
- 折叠
摘要
吞噬细胞还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶又称NOX2,是一种多组分酶复合物,在宿主免疫防御和免疫调节中发挥重要作用.NOX2组分功能缺陷会导致慢性肉芽肿病(chronic granulomatous disease,CGD).NOX2缺陷引起的固有免疫反应改变是CGD感染性疾病发生的主要原因.随着对CGD发病机制的深入研究,发现NOX2缺陷能够影响T、B细胞介导的免疫应答,进而影响CGD患者自身免疫病的发生、发展.该文将对NOX2缺陷引起的适应性免疫的改变及其与CGD患者伴随性自身免疫病的关系进行综述.
Abstract
Phagocyte nicotinamide adenine dinucleotide phosphate oxidase(NOX2),is a multicomponent enzyme complex that plays an important role in host immune defense and immune regulation.Functional defect of NOX2 correlates with the occur-rence of chronic granulomatous disease(CGD).NOX2 deficiency may alter innate immune response which is the main cause of CGD infectious diseases.Further study on the pathogenesis of CGD finds that NOX2 deficiency may regulate T and B cell-mediated immune responses,thus affecting the occurrence and development of autoimmune diseases in CGD patients.This review discusses the changes in adaptive immunity caused by NOX2 deficiency and its relationship with concomitant autoim-mune diseases in CGD patients.
关键词
吞噬细胞还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶/慢性肉芽肿病/适应性免疫/自身免疫病Key words
phagocytic nicotinamide adenine dinucleotide phosphate oxidase/chronic granulomatous disease/adaptive immunity/autoimmune diseases引用本文复制引用
出版年
2024
NETL
NSTL
万方数据