Effects of NOX2 in adaptive immune response and its correlation with autoimmune diseases associated with chronic granulomatous disease
Phagocyte nicotinamide adenine dinucleotide phosphate oxidase(NOX2),is a multicomponent enzyme complex that plays an important role in host immune defense and immune regulation.Functional defect of NOX2 correlates with the occur-rence of chronic granulomatous disease(CGD).NOX2 deficiency may alter innate immune response which is the main cause of CGD infectious diseases.Further study on the pathogenesis of CGD finds that NOX2 deficiency may regulate T and B cell-mediated immune responses,thus affecting the occurrence and development of autoimmune diseases in CGD patients.This review discusses the changes in adaptive immunity caused by NOX2 deficiency and its relationship with concomitant autoim-mune diseases in CGD patients.
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