Immunological mechanisms of the regulatory effects of gut microbiota on the pathogenesis and progression of parenteral tumors
Gut microbiota dysbiosis exists in patients with different types of cancer,including melanoma,breast cancer,brain glioma,and other parenteral solid tumors.Dysregulated gut microbiota induces the formation of immunosuppressive tumor microenvironment through a variety of mechanisms,causes the occurrence of tumor immune escape,and affects the host's responses to immune checkpoint inhibitors(ICI).The regulatory effects of gut microbiota can enhance the function of immune killer cells and inhibit tumor progression.This review summarizes the regulatory effect of gut microbiota on the progression of parenteral solid tumors and the underlying immunological mechanisms,so as to provide insights for further basic research and clinical application.
gut microbiotaparenteral solid tumorimmune checkpointtumor immune escapeimmunotherapy
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