作为一种膜蛋白,晚期糖基化终末产物受体(receptor for advanced glycation end product,RAGE)是免疫球蛋白超家族的一员.在过去的10余年里,已有数百篇文献描述了 RAGE与重症肺炎、哮喘、慢性阻塞性肺疾病、特发性肺纤维化和肺癌等肺部疾病的病理生理状态或预后的相关性,然而,研究结果并不一致.该文综述了 RAGE的来源和生物学功能,并探讨了 RAGE在肺部疾病中的作用机制及中医药对其的干预作用,旨在为改善肺部疾病提供新思路和新方法.
Research progress on the correlation of RAGE and pulmonary diseases and intervention by traditional Chinese medicine
Receptor for advanced glycation end products(RAGE),a type of membrane protein,is a member of the immuno-globulin superfamily.Over the past ten years,hundreds of papers have described the correlation between RAGE and the patho-physiological status and prognosis of lung diseases including severe pneumonia,asthma,chronic obstructive pulmonary disease,idiopathic pulmonary fibrosis,and lung carcinoma.However,many findings were inconsistent.This review summarizes the origin and biological function of RAGE.It also discusses the acting mechanism of RAGE in lung diseases and the therapeutic effect of traditional Chinese medicine via RAGE regulation,aiming to provide new ideas and strategies for improving related lung diseases.
receptor for advanced glycation end productlung diseasetraditional Chinese medicine
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