Research progress on CD 169 in macrophage-involved diseases
Sialoadhesin,also known as CD169,is an adhesion and endocytic receptor of macrophages that can recognize sialic acid.CD169 is a highly conservative molecule in evolution.Under physiological conditions,CD169 is expressed on the surface of macrophage subpopulations in secondary lymphoid tissues.Several studies have demonstrated that CD169+macrophages can phagocytize pathogens by interacting with α2,3-and α2,6-sialic proteins,and can also coordinate with DC to cross-present antigens to T cells.Moreover,CD169 can exert an immunosuppression role by inhibiting the expression of type Ⅰ IFN in macrophages.Recently,the roles of CD169+macrophages in various pathological conditions have been reported.It has been shown that when erythropoiesis is under stress,CD169+macrophages can bind to CD43 of erythroblast and affect erythroblast differentiation.In addition,CD169 has been reported to play a dual role during pathogen infection or tumor progression.This review will focus on the advance progress of CD169 and the function of CD169+macrophage,as well as its role in various diseases including virus infection,tumor development,and hematological diseases.
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