病毒感染诱导线粒体损伤在T细胞衰老中作用的研究进展
Research progress of the functions of virus infection-induced mitochon-drial damage in T cell senescence
熊君 1王晓艳 2周云 2范超 2张颖2
作者信息
- 1. 空军军医大学第二附属医院 传染科,西安 710038;西安医学院,西安 710068
- 2. 空军军医大学第二附属医院 传染科,西安 710038
- 折叠
摘要
衰老是机体代谢过程中的一个必然阶段,免疫系统也受衰老影响,其中T细胞的变化最明显.线粒体功能障碍是引起细胞衰老的重要原因之一.近年的研究发现,病毒感染可通过诱导线粒体损伤改变宿主代谢,引起机体发生免疫衰老.该文旨在综述病毒感染诱导线粒体损伤在T细胞衰老中的作用及机制研究进展,从线粒体功能、病毒感染对线粒体功能的影响以及线粒体损伤与T细胞衰老的关系等方面进行了阐述.
Abstract
Aging is an inevitable stage in the metabolic process of human body which also affects the immune system,among which the changes of T cells are the most obvious.Mitochondrial dysfunction is one of the important reasons for cellular senes-cence.Recent studies have shown that viral infection can alter the metabolism of host cells by inducing mitochondrial damage which causes immunosenescence.This review aims to summarize the research progress on the role of virus infection-induced mitochondrial damage in T cell senescence including mitochondrial function,the effect of virus infection on mitochondrial damage,and the relationship between mitochondrial damage and T cell senescence.
关键词
细胞衰老/病毒感染/免疫衰老/线粒体损伤/T细胞Key words
cellular senescence/viral infection/immunosenescence/mitochondrial dysfunction/T cell引用本文复制引用
出版年
2024
NETL
NSTL
万方数据