Research progress of protein kinase CK2 in regulating the function of tumor-related signaling pathways
Protein kinase CK2 is a highly conserved and ubiquitous protein kinase which phosphorylates a variety of protein substrates,and is involved in the regulation of several signaling pathways.Abnormal CK2 expression can lead to dysregulation of various signaling pathways,which is closely related to tumorigenesis and progression.This review summarizes the composition,structure and regulatory role of CK2 in important tumor-related signaling pathways and provides foundation to further explore CK2-targeted therapeutic strategies in cancer.
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