B cells are the major component in the tumor microenvironment and play key roles in tumor immunity.Previous studies have suggested that B cells promote tumor progression via secreting immune-inhibitory cytokines or activating the complement system through B cell-secreted antibodies.However,recent studies have revealed an important role of B cells in anti-tumor immune responses.This review summarizes the multiple functions of B cells in tumor immunity and discusses the underlying mechanisms and the effects on patients prognosis.
tumor immunityB cellregulatory B celltumor microenvironment
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