Research advances on the tumor microenvironment and new immunotherapy strategies for medulloblastoma
Medulloblastoma(MB)is the most common pediatric brain malignancy,with a 5-year overall survival(OS)rate of around 70％.In recent years,the role of the tumor microenvironment on tumor growth has attracted extensive attention.The interaction between tumor cells and other cells in the tumor microenvironment including tumor-associated macrophages(TAM),T cells,NK cells,B cells,and tumor-associated astrocytes(TAA)plays an important role in the onset and progres-sion of MB.Understanding the tumor immune microenvironment of this tumor,especially the relationship between tumor and immune cells,is crucial for the effective development of immune-based therapeutic strategies for MB.This review summarizes the latest research progress on the tumor microenvironment and immunotherapy of MB.
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