Research advances of IL-37 in the pathogenesis of allergic airway diseases
Allergic rhinitis and allergic asthma are the most common allergic airway diseases.IL-37 plays anti-inflammatory roles in allergic airway diseases by binding to IL-18Rα.On the other hand,IL-37 also binds to IL-18BP,which inhibits its binding to IL-18Rα.Therefore,a thorough understanding of the role of IL-37 in allergic airway diseases and its action mechanisms are imperative for the treatment of allergic airway diseases,and the development of IL-37-related biological agents.