Research progress on treatment methods for psoriasis
Psoriasis is an immune-mediated inflammatory skin disease involving the interaction between keratinocytes and immune cells.Depending on the severity of the patient's condition,psoriasis treatment can be categorized into three types:topical treatment,phototherapy,and systemic treatment.Topical treatment is primarily targeted at patients with mild to moderate psoriasis.However,it faces challenges such as poor skin permeability and low drug retention rates on the skin.Furthermore,systemic treatments administered orally or through parenteral routes also have some drawbacks,including hepatotoxicity and the need for healthcare professionals for administration.To address the issues associated with existing treatment methods,researchers have designed a microneedle-based drug delivery system.Microneedles(MNs)can disrupt the outermost layer of the skin,allowing drug delivery to deeper skin regions.By adjusting the height of the needles,the system can deliver anti-psoriatic drugs locally or systemically without causing any pain.Therefore,MNs are considered a promising therapeutic system.This article provides a comprehensive review of various psoriasis treatment methods,including topical,phototherapy,and systemic treatments,along with their limitations.It introduces five types of MNs:solid MNs,hollow MNs,coated MNs,dissolving MNs,and hydrogel-forming MNs,offering prospects for their future applications.
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维普
