体外血液循环冠状动脉亚低温控制装置研制
Development of Extracorporeal Blood Circulation Coronary Artery Hypothermia Control Device
钱志文 1陈明惠 1范骎 2闫小响2
作者信息
- 1. 上海理工大学健康科学与工程学院,上海介入医疗器械工程技术研究中心,上海 200093
- 2. 上海交通大学医学院附属瑞金医院心脏内科,上海 200025
- 折叠
摘要
目的 亚低温治疗可以减小心肌梗死面积,提高心肌存活率,改善远期预后.针对国内亚低温治疗仪普遍采用外源性灌注液进行灌注治疗、不良反应较多、设备体积和质量大、温控精度不高等问题,该文设计了一种便携、控温准确的体外血液循环冠状动脉亚低温控制装置.方法 温控系统使用半导体制冷片作为冷源,并重新设计制冷装置,结合模糊PID控制技术,实现对温度的准确控制.建立温控系统模型,使用阶跃响应法辨识系统参数,最后搭建实验平台,进行温控实验.结果 该体外血液循环冠状动脉亚低温控制装置结构简单,抗干扰能力强.在被控液体温度控制能力实验中,温度响应迅速,能快速到达设定的温度,稳态误差在±0.1℃以内.在模拟亚低温控制实验中,混合液温度在实验开始后145s到达设定的温度,并且稳定在 34±0.1℃.结论 该文提出的体外血液循环冠状动脉亚低温控制装置与传统设备相比在便携性和温控精度上有较大提升,对提高心肌梗死患者的生存质量具有重要意义.
Abstract
Objective Hypothermia therapy can reduce the size of myocardial infarction,increase myocardial survival,and improve long-term prognosis.In view of the problems that the domestic hypothermia therapeutic devices generally use exogenous perfusion fluid for perfusion treatment,which have many adverse reactions,the devices have large volume and weight,and the temperature control accuracy is not high,the article designs a portable and accurate temperature-controlled coronary artery hypothermia control device based on extracorporeal blood circulation.Methods In the temperature control system,semiconductor cooling chips are used as cold sources,and the cooling device is redesigned and combined with fuzzy PID control technology to achieve accurate temperature control.The temperature control system model is established,the system parameters are identified using the step response method,and finally the experimental platform for temperature control experiments is set up.Results The hypothermia control device for extracorporeal blood circulation coronary artery has a simple and easy structure,and strong anti-interference ability.In the experiment of temperature control capability of the controlled liquid,the temperature response is rapid,reaching the set temperature quickly,and the steady-state error is within±0.1℃.In the simulated hypothermia control experiment,the temperature of the mixture reached the set temperature in 145 seconds after the start of the experiment and remained stable at 34±0.1℃.Conclusions The hypothermia control device proposed in this article has greatly improved portability and temperature control accuracy compared with conventional equipment,and is of great signifi-cance for improving the life quality of life of patients with myocardial infarction.
关键词
亚低温治疗/体外血液循环/半导体制冷/模糊PIDKey words
Hypothermia Therapy/Extracorporeal Blood Circulation/Semiconductor Cooling/Fuzzy PID引用本文复制引用
出版年
2024
NETL
NSTL
万方数据