Preparation of Curcumin Nanopowder Based on Antisolvent Crystallization Method
To explore and determine the formula and process for preparing curcumin nanopowder by antisolvent crystallization method.Particle size,release curve,yield,etc.are used as inspection indicators to determine parameters such as solvent type,solution concentration,stirring method,solvent to anti-solvent volume ratio,reaction temperature,spray speed,surfactant type,and placement time.The formula is optimized through orthogonal experiments,and high temperature,high humidity and light tests are conducted to verify the stability of the nanopowder.The optimal process are as follows:the concentration of curcumin ethanol solution is 5 mg/mL,the aqueous solution of Poloxamer 188 is used as the anti-solvent,the volume ratio of solvent to anti-solvent is 1:5,and the anti-solvent is 55℃.The curcumin solution is sprayed at 1.0 mL/min,mixed with an ultrasonic oscillator,leaving it for 8 hours after mixing evenly,to separate,and dry under reduced pressure.Stability test results show that the properties and release performance of nanopowder are stable under high temperature and light conditions,but are easy to agglomerate under high humidity conditions and the release degree is significantly reduced.
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