In order to improve the extraction rate of coumarin from palmetto seeds,the interaction between influencing factors cannot be fully considered by the traditional investigation method,so the response surface optimization method based on the nonlinear model to obtain the high-precision regression equation is reasonably predicted to find out the optimal process conditions.The optimal process conditions for coumarin in palmetto seeds were established by response surface optimization method:solid-liquid ratio of 1:30,ultrasonic time of 22 min,ethanol concentration of 50％,and the extraction rate of coumarin in palmetto seeds was 5.43％,and the optimized extraction conditions could significantly improve the extraction rate of coumarin,improve the reproducibility and accuracy of the experiment,reduce energy consumption,reduce production costs,and improve product quality.
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