Clinical follow-up study of SARS-CoV-2 Omicron infection
[Objective]To observe the clinical course and explore the risk factors for SARS-CoV-2 RNA negative conversion duration(NCD)in asymptomatic and mild-symptomatic patients infected with the SARS-CoV-2 Omicron variant.[Methods]Clinical data were collected from 244 confirmed cases of corona virus disease(COVID-19)with Omicron variant infection admitted to a temporal makeshift hospital in Shanghai from April 9,2022 to May 20,2022.Demographic and clinical data were analyzed,with a primary focus on the time of COVID-19 nucleic acid conversion.Univariate and multivariate Cox regression analysis were used to determine identify risk factors associated with NCD.[Results]The median duration of negative RNA conversion was 9 days(ranged 7‒12 days).The percentage of patients with positive nucleic acid results on the 5th,7th,10th,and 14th days after confirmed infection was 68.4%,47.1%,20.1%,and 5.7%,respectively.Kaplan-Meier curves indicated a median nucleic acid conversion time of 12 days(ranged 10‒14 days)for patients with hypertension,9 days(ranged 7‒11 days)in patients without hypertension,and 11 days(ranged 9‒13 days)for patients aged≥60 years,and 9 days(ranged 7‒11 days)for patients aged<60 years.Multivariate Cox regression analysis showed that only hypertension was an independent risk factor of NCD(RR=1.60;95%CI:1.03‒2.49,P=0.036).[Conclusion]In asymptomatic or mildly symptomatic patients infected with the Omicron variant,20.1%patients continue to exhibit positive viral nucleic acid on the 10th days of infection.The independent risk factor associated with the conversion of SARS-CoV-2 nucleic acid to negative is hypertension.
万方数据
维普
