Severity of COVID-19 reinfection among healthcare workers in a grade A tertiary hospital in Shanghai by the end of 2022
[Objective]To describe the epidemic characteristics of COVID-19 after policy adjustment from"Category B notifiable disease with category A management"to"Category B notifiable disease with category B management",and to explore the protective effect of previous infection with SARS-CoV-2 on common symptoms of reinfection.[Methods]Healthcare workers infected with SARS-CoV-2 in a grade A tertiary hospital in Shanghai were included in the study from December 4,2022 to January 11,2023.Data on demographic characteristics,clinical symptoms,medical history,and COVID-19 vaccination history were collected.We determined the epidemiological curve and characteristics,and then compared the difference in the severity of clinical symptoms between primary and reinfection subjects.[Results]A total of 2 704 cases were included in the study,of which 45 had reinfection,605(22.4%)were males,608(22.5%)were doctors,1 275(47.2%)were nurses,and 2 351(86.9%)received≥3 doses of COVID-19 vaccination.The average age of these healthcare workers was(34.9±9.1)years old.The number of cases with mild/moderate illness,asymptomatic infection,fever,headache,dry cough,expectoration,and chest tightness were 2 704(100.0%),92(3.4%),2 385(88.2%),2 066(76.4%),1 642(60.7%),1 807(66.8%),and 439(16.2%),respectively.Reinfection was a protective factor for fever(OR=0.161,P<0.001),headache(OR=0.320,P<0.001),and peak body temperature(β=-0.446,P<0.001).[Conclusion]Following the COVID-19 policy adjustment as a category B notifiable disease,healthcare workers at a grade A tertiary hospital in Shanghai predominantly experiences mild to moderate COVID-19 symptoms.Reinfection results in milder clinical manifestations,with a lower proportion of being asymptomatic.
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