Antibody levels against varicella-zoster virus in healthy individuals aged 1 to 30 years in Songjiang District of Shanghai in 2022
[Objective]To determine the antibody levels of varicella-zoster virus(VZV)in healthy individuals aged 1 to 30 years in Songjiang District of Shanghai,and to provide evidence for further development of varicella immunization strategies for healthy population.[Methods]Six village committees were selected in Songjiang District through multi-stage stratified random sampling method from July to September 2022.Healthy individuals aged 1 to 30 years old in these villages were recruited and 3‒5 mL of venous blood was collected.Anti-VZV IgG antibody was tested by ELISA.Positive rate of anti-VZV IgG antibody and geometric mean concentration(GMC)were determined.[Results]A total of 315 healthy individuals aged(10.97±8.38)years were included in this study,of which 165 were males aged(11.00±8.52)years and 150 were females aged(10.96±8.25)years.Blood samples were collected and tested for anti-VZV IgG antibody,with the overall positive rate of 55.24%(174/315).The GMC was calculated to be 99.73 mIU·mL-1,with the GMC in those tested positive for anti-VZV IgG antibody of 413.11 mIU·mL-1.The positive rate of anti-VZV IgG antibody and GMCs across age groups ranged between 13.33%‒86.67%and 16.36‒355.14 mIU·mL-1,respectively.The highest GMC was found in the group of 20‒30 years old(355.14 mIU·mL-1),followed by 132.41 mIU·mL-1 in the group of 5‒years old and 138.12 mIU·mL-1 in the group of 15‒ years old.Moreover,the positive rate was 38.47%in the group with 1-dose varicella vaccine and 63.49%in the group with 2 doses,while the GMC were 53.28 mIU·mL-1 and 130.79 mIU·mL-1 in these two groups,respectively.Multivariable analysis revealed that occupation was a risk factor associated with anti-VZV IgG antibody(OR=2.540).Stratified analysis by varicella immunization history showed that among 2-dose vaccination group,time interval since the last dose was a protective factor(OR= 0.315).[Conclusions]The overall positive rate of anti-VZV IgG antibody in healthy population in Songjiang District of Shanghai remains low.The 2-dose varicella vaccination should be strengthened to improve the coverage in susceptible population.
NETL
NSTL
万方数据
维普
