Analysis of influencing factors of post-vaccination serologic testing in children exposed to hepatitis B virus in Tongzhou District,Beijing from 2020 to 2022
[Objective]To explore the importance of post-vaccination serological testing(PVST)for children exposed to hepatitis B virus(HBV),and analyze the factors affecting the progress of PVST.[Methods]The study focused on hepatitis B surface antigen(HBsAg)-positive pregnant women and their newborns residing in Tongzhou District,Beijing,who delivered at various obstetric institutions from January 1,2020 to March 31,2022.The obstetric institutions and community health service centers conducted follow-up visits 1 to 2 months after the children had received three doses of the hepatitis B vaccine(HepB).[Results]The vaccination rate of hepatitis B immunoglobulin(HBIg)was 100.00%(800/800),with a successful PVST follow-up rate of 85.88%(687/800)in Tongzhou District.The initial non-response rate to immunization was 0.29%(2/687),but successful immunization was achieved after re-immunization.The mother-to-infant transmission rate of hepatitis B was 0.Children who did not undergo PVST accounted for 14.13%(113/800),with the main reasons being delays due to the COVID-19 pandemic,parents'reluctance to allow venous blood collection due to the young age of the children,and loss to follow-up because children moved back to their parents'place of origin.Logistic regression analysis showed that the proportion of PVST was higher among high-risk children(OR=30.009,P=0.001),children with family residing in Beijing(OR=2.218,P=0.002),and children whose mothers were<35 years old(OR=1.687,P=0.020).[Conclusion]PVST is necessary for assessing the status of HBV immune response in newborns after vaccination with HepB.The COVID-19 pandemic impacted the implementation of PVST for children exposed to HBV.Strengthening the management of non-high-risk children,those living outside Beijing,and children with mothers aged≥35 years old may increase the rate of PVST in Tongzhou District.
children exposed to hepatitis B virus(HBV)post-vaccination serological testhepatitis B surface antigen(HBsAg)positivehepatitis B vaccine
NETL
NSTL
万方数据
