首页|超声引导下微波消融治疗甲状腺良性结节的安全性和有效性分析

超声引导下微波消融治疗甲状腺良性结节的安全性和有效性分析

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目的:分析超声引导下微波消融治疗甲状腺良性结节的安全性和有效性.方法:选取2016年6月—2017年4月在复旦大学附属中山医院接受超声引导下甲状腺良性结节微波消融术治疗的患者63例.术后进行随访,评估患者甲状腺结节的消融范围、血流情况、体积缩小率(volume reduction rate,VRR)、甲状腺功能、临床症状和并发症等.结果:在经微波消融术治疗后1、3、6和12个月时,患者VRR逐渐增大,分别为(25.0±15.7)%、(53.6±21.9)%、(68.0±18.9)%和(76.2±19.0)%,其中囊性结节的VRR大于实性结节.与治疗前相比,患者术后12个月时的症状和美容评分均显著下降(P<0.05),血清游离三碘甲状腺原氨酸、游离甲状腺素和促甲状腺激素水平没有显著变化(P>0.05).3例患者术后出现短暂的并发症,包括甲状腺激素水平异常和声音嘶哑,但未发现有食管穿孔、血肿形成、感染和气管损伤例.结论:超声引导下微波消融治疗甲状腺良性结节的疗效显著、并发症少且安全性高,值得临床推广应用.
Analysis of the safety and effectiveness of ultrasound-guided microwave ablation in the treatment of benign thyroid nodules
Objective:To explore the safety and effectiveness of ultrasound-guided microwave ablation in the treatment of benign thyroid nodules.Methods:Data from 63 patients with benign thyroid nodules who underwent ultrasound-guided microwave ablation in Zhongshan Hospital affiliated to Fudan University from June 2016 to April 2017 were retrospectively analyzed.The ablation range,blood flow,volume reduction rate(VRR),thyroid function,clinical status and complications were assessed at each follow-up.Results:The VRR gradually increased by(25.0±15.7)%,(53.6±21.9)%,(68.0±18.9)%and(76.2±19.0)%at 1-,3-,6-,and 12-month after microwave ablation.Larger VRR had achieved in mainly cystic nodules than mainly solid nodules at each follow-up.Compared to the pre-treatment period,patients exhibited a significant decrease in both symptom and cosmetic scores at 12 months after ablation(P<0.05).Furthermore,the levels of serum free triiodothyronine,free thyroxine,and thyroid-stimulating hormone did not show significant changes(P>0.05).Transient complications including thyroid dysfunction and voice change were observed in 3 cases during the follow-up.However,no cases of esophageal perforation,hematoma formation,infection and tracheal injury were identified.Conclusion:The ultrasound-guided microwave ablation for benign thyroid nodules has significant effect,few complications and high safety,which is worth extensive application by clinicians.

microwave ablationbenign thyroid nodulesultrasound

胡珂、陆志强

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复旦大学附属中山医院内分泌科 上海 200032

复旦大学附属闵行医院内分泌科 上海 201100

微波消融 甲状腺良性结节 超声

国家自然科学基金资助项目复旦大学附属闵行医院院级课题

820708892020MHLC08

2024

上海医药
上海医药行业协会

上海医药

影响因子:0.781
ISSN:1006-1533
年,卷(期):2024.45(1)
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