Research progress of artificial intelligence powered protein design and the prospect and challenges of its application in innovative biologics design
Proteins,the intricate"molecular machines"that orchestrate life's processes,hold immense potential for therapeutic applications.However,the designing and engineering of these proteins towards desired properties and functions remain a formidable challenge due to the complex interplay between the amino acid sequence,the three dimensional structure,and biological function.Artificial intelligence(AI)has been making transformative strides in various fields and its combination with protein engineering techniques offers a powerful toolkit in generating novel proteins for synthetic biology and therapeutics development.In this review,we will discuss the advancements and applications of AI in protein modeling and design and highlight the challenges and outlook of its applications.
artificial intelligenceprotein engineeringnovel proteinssynthetic biologytherapeutics development
NETL
NSTL
万方数据
维普
