Artificial intelligence-assisted protein stability optimization
Protein drugs have the advantages of strong targeting,clear mechanism of action and fewer adverse reactions,so they have great application prospects in clinic.The stability of protein is one of the most important properties of protein drugs,which is crucial for drugs'efficacy,safety and stability.In recent years,protein engineering assisted by artificial intelligence(AI)has been developed into an efficient strategy for protein molecular design,and has been widely used in protein stability prediction,drug design and antibody optimization.In this paper,we introduce several major methods of AI-assisted protein stability optimization,discuss their advantages and disadvantages and their applications in protein drug design and optimization.We also discuss the challenges and prospects of AI in protein stability design.We hope this paper will provide new ideas for researchers to develop more stable and efficient protein drugs.
NETL
NSTL
万方数据
维普
