Gene mining and molecular modification of hydroxysteroid dehydrogenase and its catalytic synthesis of ursodeoxycholic acid
The research progress in the biosynthesis of ursodeoxycholic acid with hydroxysteroid dehydrogenase as the core element in recent years is reviewed,and the challenges and future research directions for further development of this technology are proposeed,aiming to provide reference for the ursodeoxycholic acid biosynthesis.