Application of synthetic biology in modernization of traditional Chinese medicine
Traditional Chinese medicine,primarily based on medicinal plants,has been used for thousands of years in China and has made significant contributions to the health and proliferation of the Chinese nations.The bioactive compounds are the pharmaceutical basis for Chinese medicine.The identification of the composition of active components in Chinese medicine and the establishment of their green,low-cost manufacturing technoogies would play key roles in the promotion of the modernization of Chinese medicine.The recent development of synthetic biology not only provides new avenues for the green,low-cost and large-scale production of bioactive components of Chinese medicine but also offers technical support and necessary compounds for clarifying the composition of active components and their pharmacological mechanisms.This article reviews the development and application of synthetic biology in the production of bioactive components of Chinese medicine,such as artemisinin,ginsenosides and icaritin,and the potential roles of synthetic biology in promoting the modernization of Chinese medicine.
synthetic biologymodernization of Chinese medicinenatural productsheterologous directed synthesis
NETL
NSTL
万方数据
维普
