首页|利用支气管舒张试验结果辅助评估哮喘患者吸入性糖皮质激素治疗的有效性和规范性

利用支气管舒张试验结果辅助评估哮喘患者吸入性糖皮质激素治疗的有效性和规范性

Evaluation of the effectiveness and standardization of ICS treatment in a patient with asthma based on bronchodilator test

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1 例贲门腺癌初诊拟手术患者,术前肺功能提示重度混合性通气功能障碍,且有长期慢性咳嗽病史,予吸入ICS/LABA/LAMA联合口服复方甲氧那明改善肺功能.治疗半月后,肺功能有所改善,但支气管舒张试验阳性,提示患者诊断为哮喘(未控制).临床药师对其使用控制药物后哮喘依然控制不佳常见原因进行分析,最后发现患者吸入装置使用中吸气步骤错误,测吸气峰流速小于最低吸气流速要求30 L/min.通过药师指导,患者掌握吸入技术,测吸气峰流速为 58 L/min,达理想范围.该病例提示通过支气管舒张试验也能发现哮喘治疗是否规范,可作为ICS有效性和规范性的潜在预测因子.
A newly diagnosed patient with cardia adenocarcinoma scheduled for surgery presented with a history of long-term chronic cough and severe mixed ventilatory dysfunction was prescribed inhaled ICS/LABA/LAMA therapy in combination with oral compound methoxyphenamine capsules to improve lung function.After half a month of treatment,his lung function was improved,but the bronchodilator test showed a positive,suggesting he had a diagnosis of uncontrolled asthma.The clinical pharmacist analyzed the common causes of poor asthma control after the use of control drugs and finally found his inspiratory step was incorrect during the use of the inhalation device inhaler and the peak inspiratory flow rate was less than the minimum inspiratory flow rate of 30 L/min.Through pharmacist's guidance,he mastered the inhalation technique,and subsequently his peak inspiratory flow rate was measured to be 58 L/min,which reached the ideal range.This case suggests that bronchodilator test can also detect whether asthma treatment is standardized,which can be used as a potential predictor of the effectiveness and standardization of ICS.

bronchodilator testirregular medicationasthma

朱娜萍、金美玲、李晓宇、叶晓芬

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复旦大学附属中山医院药剂科 上海 200032

浙江中医药大学附属第二医院药剂科 杭州 310005

复旦大学附属中山医院变态(过敏)反应科 上海 200032

支气管舒张试验 不规范用药 哮喘

2024

上海医药
上海医药行业协会

上海医药

影响因子:0.781
ISSN:1006-1533
年,卷(期):2024.45(9)