临床药师参与1例肝硬化合并肺炎支原体肺炎患者抗感染治疗的药学监护
Clinical pharmacist participates in the pharmacological monitoring of anti-infective therapy in a patient with cirrhosis complicated with Mycoplasma pneumoniae pneumonia
冯广伟 1张静 1刘阳熙 2崔敏2
作者信息
- 1. 上海市徐汇区大华医院药剂科 上海 200237
- 2. 上海交通大学医学院附属仁济医院药学部 上海 200127
- 折叠
摘要
1 例肝硬化合并肺炎支原体肺炎患者应用阿奇霉素控制感染效果不佳,临床药师结合细菌耐药性、患者病理生理情况等因素,建议调整为左氧氟沙星.我国成人社区获得性肺炎支原体对阿奇霉素耐药率较高,同时阿奇霉素可能增加肝硬化患者的急性肝损伤风险和死亡率.左氧氟沙星可作为成人肺炎支原体肺炎的首选药物之一,且对于肝功能减退患者无需减量.
Abstract
A patient with liver cirrhosis complicated with Mycoplasma pneumoniae pneumonia had poor effect on azithromycin to control the infection and the clinical pharmacist recommended to adjust to levofloxacin considering the factors such as bacterial resistance and the patient's pathophysiology and so on.The resistance rate of azithromycin to adult community-acquired Mycoplasma pneumoniae in China is high,while azithromycin may increase the risk of acute liver injury and mortality in patients with liver cirrhosis.Levofloxacin may be one of the drugs of choice for Mycoplasma pneumoniae pneumonia in adults and the patients with decompensated liver function do not require dosage reduction.
关键词
肺炎支原体肺炎/肝硬化/左氧氟沙星/阿奇霉素Key words
Mycoplasma pneumoniae pneumonia/liver cirrhosis/levofloxacin/azithromycin引用本文复制引用
出版年
2024
NETL
NSTL
万方数据